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  1. ; ; (, ChemBioChem)
    Abstract Tuberculosis (TB), caused by the pathogenMycobacterium tuberculosis, affects millions of people worldwide. Several TB drugs have lost efficacy due to emerging drug resistance and new anti‐TB targets are needed. Recent research suggests that indole‐3‐glycerol phosphate synthase (IGPS) inM. tuberculosis(MtIGPS) could be such a target. IGPS is a (β/α)8‐barrel enzyme that catalyzes the conversion of 1‐(o‐carboxyphenylamino)‐1‐deoxyribulose 5’‐phosphate (CdRP) into indole‐glycerol‐phosphate (IGP) in the bacterial tryptophan biosynthetic pathway.M. tuberculosisover expresses the tryptophan pathway genes during an immune response and inhibition ofMtIGPS allows CD4 T‐cells to more effectively fight againstM. tuberculosis. Here we review the published data onMtIGPS expression, kinetics, mechanism, and inhibition. We also discussMtIGPS crystal structures and compare them to other IGPS structures to reveal potential structure‐function relationships of interest for the purposes of drug design and biocatalyst engineering. 
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